RELATIONSHIP OF HYPERTENSION WITH AORTIC CALCIFICATION IN CHEST X-RAY IMAGES OF PATIENTS AT RSUP KEYWORDS HAJI ADAM MALIK MEDAN
Main Article Content
Hypertension serves as an independent risk factor for atherosclerosis development and is linked to factors that predispose to aortic calcification. Furthermore, hypertension has the potential to cause the acute rupture of existing plaques by elevating mechanical pressure on them. Chest X-ray imaging is a commonly employed method for identifying aortic calcification during routine examinations. Medial arterial calcification is visualized as radiopaque findings resembling tram-tracks, while calcification within the intima is observed as radiopaque spots.A cross-sectional study involving 92 hypertensive individuals who underwent chest X-ray imaging at RSUP Haji Adam Malik Medan aimed to assess the distribution of study subjects in terms of age, gender, hypertension severity, and aortic calcification degree. Hypertension history was extracted from patients' medical records, and aortic calcification measurements were conducted in the aortic arch by both the researcher and a radiologist. The majority of hypertensive patients were aged over 65, accounting for 40.2% of the sample, with a predominant female population of 57.6%. Stage 1 hypertension was the most prevalent, affecting 52.2% of the subjects, and grade one aortic calcification was the most common, observed in 63% of cases.A weak yet statistically significant positive correlation between hypertension and aortic calcification was identified (p < 0.05; r = 0.196) in the patient population at RSUP Haji Adam Malik Medan.
Adrian, S. J. Tommy. (2019). Hipertensi Esensial: Diagnosis dan Tatalaksana Terbaru pada Dewasa. Vol. 46. No. 3. Cermin Dunia Kedokteran.
Albanese, I., et al. (2018). Atherosclerotic calcification: Wnt is the hint. Journal of the American Heart Association, 7(4). Available at: https://doi.org/10.1161/jaha.117.007356.
Aziz, M., & Yadav, K. S. (2016). Pathogenesis of Atherosclerosis. Med Clin Rev, 2:3.
Bendix, E. F., et al. (2018). Diabetes and abdominal aortic calcification—a systematic review. Current Osteoporosis Reports, 16(1).
Budoff, M. J., Shaw, L. J., Liu, S. T., et al. Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients. Journal of the American College of Cardiology, 49(18).
Chobanian, A. V., et al. (2003). The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA, 289.
Claudie Petit, S. Jamaleddin M, Stéphane A. (2019). Chapter 6 - Review of the Essential Roles of SMCs in ATAA Biomechanics. Advances in Biomechanics and Tissue Regeneration.
Demer, L. L., & Tintut, Y. (2008). Vascular calcification: pathobiology of a multifaceted disease. Circulation.
Demer, L. L., & Tintut, Y. (2008). Vascular calcification: pathobiology of a multifaceted disease. Circulation.
Extracellular vesicle signalling in atherosclerosis - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Atherosclerotic-plaque-formation-A-Lipoprotein-retention-to-the-vascular-wall-and_fig1_343901409.
Farhanah, RD. (2019). Korelasi Derajat Hipertensi dengan Derajat Kalsifikasi Arkus Aorta pada Foto Toraks di RSUP Dr. Mohammad Hoesin Palembang. Fakultas Kedokteran Universitas Sriwijaya.
Guideline for the pharmacological treatment of hypertension in adults. Geneva: World Health Organization; 2021. Licence: CC BY-NC-SA 3.0 IGO.
Hak, A. E., Pols, H. A., Stehouwer, C. D., et al. Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam Study. Journal of Clinical Endocrinology and Metabolism, 86(2).
Hjortnaes, J., New, S. E. P., & Aikawa, E. (2013). Visualizing novel concepts of cardiovascular calcification. Trends in Cardiovascular Medicine, 23(3).
Hiroko Hashimoto, Katsuya Iijima, Masayoshi Hashimoto, Bo-Kyung Son, Hidetaka Ota, Sumito Ogawa, Masato Eto, Masahiro Akishita, Yasuyoshi Ouchi. (2009). Validity and Usefulness of Aortic Arch Calcification in Chest X-Ray. Journal of Atherosclerosis and Thrombosis, 16(3).
HS, F.R. (2014) “Diagnosis and Management of Hypertension in the Elderly Patient,” Medical Journal of Lampung University, 3(7).
Iqbal, A. M., & Jamal, S. F. (2022). Essential Hypertension. StatPearls. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539859/.
Iribarren, C., et al. (2000). Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke and peripheral vascular disease. Journal of American Medical Association, 283(16).
Jarjou'i, A., Bogot, N., Kalak, G., Chen-Shuali, C., Rokach, A., Izbicki, G., & Arish, N. (2021). Diffuse pulmonary calcifications: A case series and review of literature. Respirology case reports, 9(10).
Jebari-Benslaiman, S. Galicia-García, U. Larrea-Sebal, A. Olaetxea, J.R. Alloza, I. Vandenbroeck, K. Benito-Vicente, A. Martín, C. (2022). Pathophysiology of Atherosclerosis. Int. J. Mol. Sci.
Jung, J. G., Wu, L. T., Kim, J. S., Kim, E. D., & Yoon, S. J. (2019). Relationship between Smoking and Abdominal Aorta Calcification on Computed Tomography. Korean journal of family medicine, 40(4).
Kramann R, Schüler P, Risler T, et al. Mechanisms of vascular calcification. Am J Physiol Renal Physiol. 2019.
Kuswardhani RAT. (2006). Penatalaksanaan hipertensi pada lanjut usia. Jurnal Penyakit Dalam, 7(2).
Lombardi M, Severi P, Mazza A et al. (2017). Sex differences in hypertension: A question worth asking? Ann Clin Hypertens,1.
Mahayuni, KS. (2021). Gambaran Tingkat Pengetahuan Tentang Hipertensi Pada Pasien Hipertensi Di RSUD Kabupaten Klungkung Tahun 2021. Diploma thesis, Jurusan Keperawatan Poltekkes Denpasar.
Messerli, M., Giannopoulos, A. A., Leschka, S., Warschkow, R., Wildermuth, S., Hechelhammer, L., & Bauer, R. W. (2017). Diagnostic accuracy of chest X-ray dose-equivalent CT for assessing calcified atherosclerotic burden of the thoracic aorta. The British journal of radiology.
Muhammad, M. (2022). HUBUNGAN HIPERTENSI DENGAN KALSIFIKASI ARKUS AORTA PADA FOTO TORAKS PASIEN STROKE ISKEMIK DI RSUP. H. ADAM MALIK MEDAN [Preprint].
Nakanishi, R., Baskaran, L., Gransar, H., Budoff, M. J., Achenbach, S., Al-Mallah, M., Cademartiri, F., Callister, T. Q., Chang, H. J., Chinnaiyan, K., Chow, B., DeLago, A., Hadamitzky, M., Hausleiter, J., Cury, R., Feuchtner, G., Kim, Y. J., Leipsic, J., Kaufmann, P. A., Maffei, E., … Berman, D. S. (2017). Relationship of Hypertension to Coronary Atherosclerosis and Cardiac Events in Patients With Coronary Computed Tomographic Angiography. Hypertension (Dallas, Tex. : 1979), 70(2).
Nuraini, B. (2015). “Risk Factors of Hypertension,” Jurnal Kedokteran UNILA, 4(5).
Nuraima A. (2012). Faktor risiko hipertensi pada masyarakat di Desa Kabongan Kidul kabupaten Rembang [Laporan Penelitian]. Semarang: Universitas Diponegoro.
Noviyanti. (2015). Hipertensi Kenali, Cegah, dan Obati. Diterbitkan Oleh Notebook. Bantul, Yogyakarta.
Odink, A., van der Lugt, A., Hofman, A., et al. Risk factors for coronary, aortic arch and carotid calcification; The Rotterdam Study. J Hum Hypertens.
Pinto E. Blood pressure and ageing. Postgrad Med J. 2007.
Shah, N. M., Dong, Y., & Cao, J. (2018). Association of androgen and estrogen with hypertension in postmenopausal women: a cross-sectional study from NHANES. Clinical and Experimental Hypertension, 40(7).
Shanahan CM. (2007). Inflammation ushers in calcification: a cycle of damage and protection?. Circulation.
Shanahan CM, Crouthamel MH, Kapustin A, et al. (2011). Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate. Circ Res.
Shanahan CM, Crouthamel MH, Kapustin A, et al. (2011). Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate. Circ Res.
Shanahan, C.M., Crouthamel, M.H., Kapustin, A. et al. (2011). Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate. Circ Res. 2011;109(6):697-711.
Supriyono, S., & Andriyanto, A. (2020). Relationship of characteristics (age, sex, level of education) with hypertension in training of healthy family trainers. Jurnal Ilmu Kesehatan, 8(2).
Tadic M, Cuspidi C, Grassi G et al. (2019) Gender-specific therapeutic approach in arterial hypertension—Challenges ahead. Pharmacological Research, 141.
Tadic, M., Cuspidi, C., Grassi, G., et al. (2019). Gender-specific therapeutic approach in arterial hypertension—Challenges ahead. Pharmacological Research, 141.
Tanzil, E.K., and Widjaya, I.F. (2022). Hubungan Jenis Kelamin dengan Kalsifikasi Aorta pada Radiografi Toraks. HUBUNGAN JENIS KELAMIN DENGAN KALSIFIKASI AORTA PADA RADIOGRAFI TORAKS, 6(3).
Themes, U. (2019, May 29). Vascular system. Radiology Key.
Tsakiris, A. et al. (2004). Aortic calcification is associated with age and sex but not left ventricular mass in essential hypertension, Journal of clinical hypertension (Greenwich, Conn.).
Woo, J. S., Kim, W., Kwon, S. H., Youn, H. C., Kim, H. S., Kim, J. B., Kim, S. J., Kim, W. S., & Kim, K. S. (2016). Aortic arch calcification on chest X-ray combined with coronary calcium score show additional benefit for diagnosis and outcome in patients with angina. Journal of geriatric cardiology: JGC, 13(3).
Yunitasari, PY. (2018). Hubungan Karakteristik Pasien Hipertensi Dengan Perilaku Kontrol Tekanan Darah Di Upt Kesmas Gianyar I Tahun 2018. Diploma thesis, Jurusan Keperawatan 2018.