PHYTOCHEMICAL EVALUATION OF ANTI-INFLAMMATORY AGENTS OF STARFRUIT LEAF EXTRACT (Averrhoa bilimbi) FROM URBAN AREA
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Tahara Dilla Santi
Aditya Candra
Ika Waraztuty
Andri
Said Aandy Saida
Syarifah Nora Andriaty
Inflammation is the body's natural defense mechanism against infection or injury.This study aims to evaluate the phytochemical compounds contained as anti-inflammatory agents in starfruit leaves grown in urban areas. The methods used in the study include laboratory tests to obtain soil characteristics including physical and chemical properties, phytochemical screening tests and GC-MS to obtain accurate data related to the bioactive compounds contained in starfruit leaves. The results showed that starfruit leaves contain alkaloids, steroids, saponins, flavonoids, phenolics, and terpenoids, but no tannins were found. This may be due to the clay soil structure where the plant grows which affects the secondary metabolites produced. Furthermore, the GC-MS test obtained thirteen compounds which are anti-inflammatory agents including 2-(p-tolymethyl)-p-xylene; cis-tricyclo [7.5.0.0(2,8)]tetradeca-7,9-diene; (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-ol; (2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-ol; Dimethyl (3S,4R,5S,6R)-3,6-dimethylcyclohexene-4,5-dicarboxylate; 9,12,15-Octadecatrienol; Palmitic acid; 2-amino-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carbonitrile; 2(3H)-Phenanthrenone, 4,4a-dihydro-4a-methyl-; 4,8-Dimethyl-3,7-nonadien-2-ol; Benzofuran, 2,3-dihydro-; Acrylic acid; 4-Hydroxy-3-methyl-2H-pyran-2-one.
Alhassan, A., & Ahmed, Q. (2016). Averrhoa bilimbi Linn.: A review of its ethnomedicinal uses, phytochemistry, and pharmacology. J Pharm Bioallied Sci, 6(4), 265–271. https://doi.org/10.4103/0975-7406.199342
Bhardwaj, P., Kumar Jain, C., & Mathur, A. (2019). Comparative analysis of saponins, flavonoids, phenolics and antioxidant activities of field acclimatized and in vitro propagated Bacopa monnieri (L.) Pennell from different locations in India. Indian Journal of Experimental Biology, 57(April), 259–268.
Bünemann, E. K., Bongiorno, G., Bai, Z., Creamer, R. E., De Deyn, G., & de Goede, R., Fleskens, L., Geissen, V., Kuyper, T. W., Mäder, P., Pulleman, M. M., Sukkel, W., van Groenigen, J. W., and Brussaard, L. (2018). Soil quality – A critical review, Soil Biol. In Biochem (120th ed., pp. 105–125).
Candra, A., Fahrimal, Y., Yusni, Azwar, & Santi, T. D. (2023). Soil Chemistry, Phytochemistry, and GC-MS Profils of Moringa Leaves (Moringa oleifera) as an Antifatigue Candidate From Geothermal, Coastal, and Urban Areas in Aceh Besar District and Banda Aceh Municipality, Indonesia. Rasayan Journal of Chemistry, 16(3), 1333–1341. https://doi.org/10.31788/RJC.2023.1638128
Candra, A., Fahrimal, Y., Yusni, Azwar, & Santi, T. D. (2024). Phytochemistry and antifatigue activities of Carica papaya leaf from geothermal, coastal and urban areas, Indonesia. Narra J, 4(1), 1–9. https://doi.org/http://doi.org/10.52225/narra.v4i1.321
Candra, A., & Santi, T. D. (2017). Efektivitas Ekstrak Daun Pepaya (Carica papaya L) sebagai antiinflamasi. Jurnal Aceh Medika, 1(2), 63–66. http://jurnal.abulyatama.ac.id/index.php/acehmedika/article/view/145
Candra, A., Santi, T. D., Waraztuty, I., Yani, M., & Saida, S. A. (2025). The Relationship Between The Chemical Properties Of Soil And The Compounds Squalene And Linolenic Acid. MEedalion Journal: Medical Research, Nursing, Health and Midwife Participation, 2(2), 123–130. https://doi.org/https://doi.org/10.59733/medalion.v6i2.192
Candra, A., Santi, T. D., Yani, M., & Maidayani, M. (2023). Sosialisasi Pencegahan Stunting di Wilayah Kerja Puskesmas Kuta Malaka. Jurnal Abdimas Unaya, 4(1), 6–11. http://jurnal.abulyatama.ac.id/index.php/Abdimas/article/view/3928/pdf_1
Candra, A., Santi, T. D., Yani, M., & Mawaddah, D. S. (2022). Faktor-Faktor yang Berhubungan dengan Kejadian Hipertensi di Desa Baet Lampuot Aceh Besar. Media Kesehatan Masyarakat Indonesia, 21(6), 418–423.
Gunawan, C., & A., P. (2013). Structure Elucidation of Two New Phytol Derivatives, a New Phenolic Compound and Other Metabolites of Averrhoa bilimbi. Research Congress, De La Salle University Manila., 1–8.
Hou, C., Chen, L., Yang, L., & Ji, X. (2020). An insight into anti-inflammatory effects of natural polysaccharides. International Journal of Biological Macromolecules, 153, 248–255. https://doi.org/10.1016/j.ijbiomac.2020.02.315
Huang, S., Li, S., Li, G., Wang, C., Guo, X., Zhang, J., Liu, J., Xu, Y., & Wang, Y. (2024). Fabrication and Characterization of Phyllanthus Emblica Extract-Polyvinyl Alcohol/Carboxymethyl Cellulose Sodium Antioxidant Hydrogel and Its Application in Wound Healing. Pharmaceutics, 16(12), 1531. https://doi.org/10.3390/pharmaceutics16121531
Isir, S., Tamod, Z. E., & Supit, J. M. J. (2022). Identifikasi Sifat Kimia Tanah Pada Lahan Tanaman Bawang Merah (Allium ascalonicum,L.) Di Desa Talikuran Kecamatan Remboken Kabupaten Minahasa. Soil Environmental, 22(1), 6–11.
Jakovljevic, M., Kostic, N., & Antic-Mladenovic, S. (2003). The availability of base elements (Ca, Mg, Na, K) in some important soil types in Serbia. Proc. Nat. Sci. Matica Sr, 104, 11–21. https://doi.org/10.2298/zmspn0304011j
Kamal, M. H., Santi, T. D., & Agustina. (2024). Efektivitas Cocos Nucifera 200ml Dan 330ml Dalam Mengurangi Intensitas Nyeri Dismenore Primer Pada Remaja. MAHESA: MALAHAYATI HEALTH STUDENT JOURNAL, 4(7BACKGROUND: Despite a relative reduction in the hospitalization rate for heart failure (HF), the actual number of HF hospitalizations remains >1 million annually. More than 80% of patients who are hospitalized are initially seen in the emergency departme), 2837–2850. https://doi.org/https://doi.org/10.33024/mahesa.v4i7.14681
Kompas.com. (2022). WHO Peringatkan Kemungkinan Lonjakan Penyakit Kronis pada 2030. https://www.kompas.com/sains/read/2022/10/25/190300223/who-peringatkan-kemungkinan-lonjakan-penyakit-kronis-pada-2030
Labkesda. (2017). Prosedur Analisis GCMS Tanaman. Laboratorium Kesehatan Daerah.
Milenkovic, V., Stanton, E., Nothdurfter, C., Rupprecht, R., & Wetzel, C. (2019). The Role of Chemokines in the Pathophysiology of Major Depressive Disorder. Int J Mol Sci, 9(20), 9.
Muhammad, A., Ahmed, Q. U., & Linn, A. B. (2016). Averrhoa bilimbi Linn .: A review of its ethnomedicinal uses , phytochemistry , and pharmacology Phytochemical Constituents Role of Averrhoa Bilimbi as an Antimicrobial Agent Role of Averrhoa Bilimbi as an Antioxidant Agent Role of Averrhoa Bilimbi as a H. Journal of Pharmacy and Bioallied Sciences, 8(4), 265–271.
National Library of Medicine. (2025). PubChem. https://pubchem.ncbi.nlm.nih.gov/
Neina, D. (2019). The Role of Soil pH in Plant Nutrition and Soil Remediation. Applied and Environmental Soil Science, 9.
Nelly, C., Fitriyana, L., Santi, T. D., & Saudah. (2024). Diversity of traditional vegetables and spices as local food security for the Gayo Tribe, Aceh, Indonesia. Biodiversitas, 25(12), 4699–4711. https://doi.org/10.13057/biodiv/d251206
Nwachokor, M. A., Uzu, F. O., & Molindo, W. A. (2009). Variations in Physicochemical Properties and Productivity Implications for Four Soils in the Derived Savannah of Southern Nigeria. American-Eurasian Journal of Agronomy, 2(1), 124–129.
Pahwa, R., Goyal, A., & Jialal, I. (2025). Chronic Inflammation. https://www.ncbi.nlm.nih.gov/books/NBK493173/
Raal, A., Meos, A., Hinrikus, T., Heinämäki, J., Romāne, E., Gudienė, V., Jakštas, V., Koshovyi, O., Kovaleva, A., Fursenco, C., Chiru, T., & Nguyen, H. T. (2020). Dragendorff’s reagent: Historical perspectives and current status of a versatile reagent introduced over 150 years ago at the University of Dorpat, Tartu, Estonia. Pharmazie, 75(7), 299–306. https://doi.org/10.1691/ph.2020.0438
Sá, R. D., Vasconcelos, A. L., Santos, A. V, Padilha, R. J. R., Alves, L. C., Soares, L. A. L., & Perrelli, K. (2019). Anatomy , histochemistry and oxalic acid content of the leaflets of Averrhoa bilimbi and Averrhoa carambola. Revista Brasileira de Farmacognosia, 29(1), 11–16. https://doi.org/10.1016/j.bjp.2018.09.005
Saidi, N., Ginting, B., Murniana, & Mustanir. (2018). Analisis metabolit sekunder. Syiah Kuala University Press.
Santi, T. D. (2015). Uji Toksisitas Akut dan Efek Antiinflamasi Ekstrak Metanol dan Ekstrak n-Heksana Daun Pepaya (Carica papaya L). Pharmaceutical Sciences and Research, 2(2), 101–114. https://doi.org/10.7454/psr.v2i2.3341
Santi, T. D. (2019). Effect of Moderate Physical Activity to Muscle Fatigue on Untrained People. IOP Conference Series: Materials Science and Engineering, 506(1), 0–5. https://doi.org/10.1088/1757-899X/506/1/012028
Santi, T. D. (2025). Pengembangan Patch Ekstrak Daun Salam (Syzygium polyanthum) Sebagai Agen Wound Healing Pada Luka Diabetik.
Santi, T. D., & Candra, A. (2023). Skrining Fitokimia Dan Karakteristik Salep Daun Averrhoa bilimbi. BIOMA : Jurnal Biologi Makassar, 8(1), 23–31. https://journal.unhas.ac.id/index.php/bioma/article/view/23338
Santi, T. D., & Candra, A. (2024). Analisis Senyawa Fitokimia Daun Moringa Oleifera Dari Kawasan Geotermal Aceh Besar Sebagai Kandidat Antiinflamasi. Media Penelitian Dan Pengembangan Kesehatan, 34(4), 857–866. https://doi.org/https://doi.org/10.34011/jmp2k.v34i4.2638
Santi, T. D., Candra, A., Amin, F. A., & Rizki, C. M. F. (2025). Ethnopharmacological Study of Medicinal Plants in Gampong Atong, Aceh Besar. Proceeding of International Conference Social Technology Education and Health Science, 2(1), 1–7. https://proceeding.umpri.ac.id/index.php/ISTEHS/article/view/71/80
Santi, T. D., Candra, A., & Zakaria, R. (2023). Counseling and Training of Intervention Model Local Plants to Overcome Stunting ( TALAS ) for Health Workers at Montasik Health Center, Aceh Besar. IRPITAGE, 4(2), 287–291. https://doi.org/https://doi.org/10.54443/irpitage.v4i2.2041
Santi, T. D., Siregar, T. N., Sutriana, A., Andini, R., & Candra, A. (2022). Phytochemical test and optimization of transdermal patches of Carica papaya extract : Formulation design of candidate drug for wound healing. Biodiversitas, 23(6), 2904–2913. https://doi.org/10.13057/biodiv/d230617
Santi, T. D., Siregar, T. N., Sutriana, A., Andini, R., & Candra, A. (2023). Wound Healing Activity of Transdermal Patches of Carica Papaya, Chromolaena Odorata, and Averrhoa Bilimbi Leaves on Incision Wounds of Hyperglycemic Rat. Trends in Sciences, 20(12), 6944. https://doi.org/https://doi.org/10.48048/tis.2023.6944
Santi, T. D., Zakaria, R., Candra, A., & Dharma Nauval, M. (2023). Analysis Active Compounds of Carica papaya, Averrhoa bilimbi, and Chromolaena odorata Leaves from Geothermal Area. AIP Conference Proceedings, 2583(January). https://doi.org/10.1063/5.0116236
Sari, R. A. L., Sari, R. K., Safitri, U. D., Aristri, M. A., Wahyuningrum, M., & Lubis, M. A. R. (2025). Effectiveness of Different Extraction Techniques on the Yield and Antityrosinase Activity of Merbau (Intsia bijuga (Colebr.) Kuntze) Wood Extract. Jurnal Sylva Lestari, 13(3), 642–661. https://doi.org/https://doi.org/10.23960/jsl.v13i3.1140
Sarker, M. A. M., & Chowdhury, A. Y. S. F. U. A. (2024). Acute anti-inflammatory effect of methanolic extracts of leaf, bark and fruit of Averrhoa bilimbi on carrageenan-induced acute inflammation in rats. Journal of Pharmacognosy and Phytochemistry, 13(5), 97–101.
Seebaluck-sandoram, R., Lall, N., Fibrich, B., Blom, A., Staden, V., Saleem, H., & Fawzi, M. (2019). Biocatalysis and Agricultural Biotechnology Antimicrobial , antioxidant and cytotoxic evaluation of two underutilised food plants : Averrhoa bilimbi L . ( Oxalidaceae ) and Phyllanthus acidus L . Skeels ( Phyllanthaceae ). Biocatalysis and Agricultural Biotechnology, 18(December 2018), 100998. https://doi.org/10.1016/j.bcab.2019.01.036
Singh, P. J. and D. (2014). Analysis the Physico-Chemical and Microbial Diversity of Different Variety of Soil Collected From Madhya Pradesh, India. Scholarly J. Agric. Sci, 4(2), 103–108.
Tahara, Aditya, C., Zurriyani, Z., Andri, A., Ika, W., Said, A. S., & Muhammad, Y. (2024). Potential of Averrhoa bilimbi Leaf in Incision Wound Healing in Diabetic Rat Model. BIOVALENTIA: Biological Research Journal, 10(2), 31–37. https://doi.org/10.24233/biov.10.2.2024.397
White, P. J., & Brown, P. H. (2010). Plant nutrition for sustainable development and global health. Annals of Botany, 105(7), 1073–1080. https://doi.org/10.1093/aob/mcq085
World Health Organization. (2023). The First WHO Traditional Medicine Global Summit. https://www.who.int/news-room/events/detail/2023/08/17/default-calendar/the-first-who-traditional-medicine-global-summit#:~:text=The First WHO Traditional Medicine Global Summit will take place,in Gandhinagar%2C Gujarat%2C India.
Yousuf, A., Ibrahim, W., Greening, N., & Brightling, C. (2019). Biologics for Chronic Obstructive Pulmonary Disease. J Allergy Clin Immunol Pract, 7(5), 1405–1416.
Zhang, S., Huffman, T., & Zhang, X. (2014). Spatial distribution of soil nutrient at depth in black soil of Northeast China: a case study of soil available phosphorus and total phosphorus. J Soils Sediments, 14(November), 1775–1789. https://doi.org/10.1007/s11368-014-0935-z
