MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Editor-in-Chief Muhammad Rizky, M.Ed. E-ISSN 2986-7754 Frequency 4 Issues/Year Language English Review Policy Double-Blind Peer Review Platform Open Journal Systems (OJS) Publisher PT. Radja Intercontinental Publishing Journal URL https://medalionjournal.com/index.php/go/index MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation is a peer-reviewed, open access journal which publishes original research articles and review articles in all areas of nursing and midwifery, research and education. The aim of the journal is to contribute to the growing field of nursing practice and provide a platform for researchers, physicians and healthcare professionals. Topics of interest include: Nursing education Community nursing Specialist nursing topics Policies in nursing and healthcare Ethical issues Healthcare systems Healthcare management Pediatrics nursing
EVALUATION OF THE IMPLEMENTATION OF THE ISPA CONTROL PROGRAM IN THE MANAGEMENT OF TODDLER PNEUMONIA AT THE PUTRI AYU PUBLIC HEALTH CENTER IN JAMBI CITY
Acute respiratory infections including pneumonia remain a major cause of morbidity and mortality in children under five and case detection in primary care is often low despite the availability of guidelines; Putri Ayu Community Health Center recorded 53 cases of pneumonia in children under five in 2025 with a detection coverage of 26.49% of the target of 90%, so an implementation evaluation is needed. Objective: To evaluate the implementation of the ARI Control Program in the management of pneumonia in children under five using a logic model (input → activity → output). Method: Descriptive qualitative case study at Putri Ayu Community Health Center (Dec 2024–Apr 2026) with snowball sampling (n=9 informants: manager, clinician, pharmacist, emergency department, nutritionist, and caregiver); data collection through in-depth interviews, participant observation, and document review; thematic analysis using NVivo 12 and the Miles-Huberman framework with triangulation. Results: Input was partially adequate but training was uneven and there was a shortage of nurses during peak periods; some drugs, injection preparations, forms, and ARI sound timers were unavailable or damaged; Funding is relatively sufficient but early year disbursement is hampered; SOPs exist but require cluster adjustments; program activities are inconsistent (dominant passive findings, uneven breath counts, variable antibiotic duration, pre-referral is not yet uniform, use of KIA Handbooks is lacking, monitoring does not comply with guidelines); output is low (26.49%). Conclusion: Implementation is partially in accordance with the 2018 FKTP guidelines but is not yet consistent; it is recommended to strengthen active surveillance and reporting networks, standardize clinical references, uniform training for supporting units, improve logistics and critical equipment, and improve communication and monitoring to improve case detection and management compliance
Copyright (c) 2026 Regina Cahyani, Arnild Augina Mekarisce, Adila Solida, Rumita Ena Sari https://creativecommons.org/licenses/by/4.0
RELATIONSHIP OF THE ETHMOIDAL INFUNDIBULUM, UNCINATE PROCESS, AND NASAL SEPTUM DEVIATION WITH CHRONIC MAXILLARY RHINOSINUSITIS ON PARANASAL SINUS CT SCAN IN MEDAN
Background: Chronic rhinosinusitis (CRS) is a common sinonasal inflammatory disease, with global prevalence ~10,9% (European Position Paper on Rhinosinusitis and Nasal Polyps 2021). CRS pathogenesis is associated with impaired osteomeatal complex (OMC) drainage, influenced by anatomical variations, e.g. ethmoidal infundibulum (EI) length and width, uncinate process (UP) type, and nasal septal deviation (NSD) degree. This study aims to evaluate the relationship between anatomical variations of the OMC (EI, UP, and NSD) and the occurrence of maxillary CRS based on paranasal sinus (PNS) CT. Method: cross-sectional design involved 100 maxillary sinuses from patients who underwent PNS CT at Prof. Dr. Chairuddin Panusunan Lubis Hospital. Statistical analysis was performed using Chi-square and Eta correlation tests. Result: Mean EI length in CRS (5.9 ± 2.7 mm) was shorter than in non-CRS (7.8 ± 2.6 mm, p<0.001), while EI width was greater (2.8 ± 1.1 mm vs. 2.3 ± 0.5 mm, p<0.05). UP type A was most frequent in CRS (47%, p<0.001). NSD ≥10° was more common in CRS (31%) than in non-CRS (13%, p<0.05). Conclusion: Anatomical variations of OMC play an important role in predisposition to maxillary CRS. Most patients showed Keros type 2 and Gera type 2, indicating a moderate risk of complications during functional endoscopic sinus surgery. Comprehensive evaluation using PNS CT is essential for safe and effective surgical planning.
Copyright (c) 2026 Fingga Prahasti Nasution, M.Rizky Fachri, Elvita Rahmi Daulay, Ferryan Sofyan https://creativecommons.org/licenses/by/4.0
THE RELATIONSHIP BETWEEN MEDICAL AND NON-MEDICAL STAFF INTERPERSONAL COMMUNICATION SKILLS AND OUTPATIENT PATIENT SATISFACTION AT DR. LEOKMONO HADI KUDUS REGIONAL HOSPITAL
This study is motivated by the importance of interpersonal communication between medical and non-medical staff in improving outpatient satisfaction in hospitals. The study aims to analyze the relationship between interpersonal communication skills of medical and non-medical staff and outpatient satisfaction at Dr. Loekmono Hadi Kudus Regional General Hospital. The study used a quantitative approach with an observational analytical design and a cross-sectional design. The study population was all outpatients at Dr. Loekmono Hadi Kudus Regional General Hospital with an average of 243 patient visits per day, while a sample of 152 respondents was determined using the Slovin formula with a purposive sampling technique. The research instrument used a questionnaire on interpersonal communication and patient satisfaction that had been tested for validity and reliability. Data analysis was carried out univariately and bivariately using the chi-square test. The results showed that 86.2% of respondents rated the staff's interpersonal communication skills as good and 89.5% of respondents were satisfied with outpatient services. Statistical tests showed a significant relationship between interpersonal communication skills and patient satisfaction (p = 0.001). The conclusion of this study is that good interpersonal communication contributes to increasing outpatient satisfaction in hospitals
Copyright (c) 2026 Yesy Putri Adelia, Muhammad Purnomo, Zunia Khairunisa, Fitriana Kartikasari https://creativecommons.org/licenses/by/4.0
COMPLEMENTARY BREASTFEEDING (MPASI) FEEDING PATTERNS AND HISTORY OF INFECTIOUS DISEASES IN STUNTED AND NON-STUNTED CHILDREN AGED 12-24 MONTHS IN THE GANTING COMMUNITY HEALTH CENTER AREA, GEDANGAN DISTRICT, SIDOARJO REGENCY
Stunting is a condition of growth failure that occurs in toddlers due to chronic malnutrition that occurs in the First 1000 Days of Life (HPK), starting from the formation of the fetus until the child is 24 months old. Factors that influence the incidence of stunting are direct factors (food consumption, history of infectious diseases, breastfeeding practices, food availability) and indirect factors (economic conditions, health services, education level, social and cultural aspects). This study aims to determine the pattern of complementary feeding (MPASI) and history of infectious diseases, as well as differences in the pattern of complementary feeding (MP-ASI) and history of infectious diseases in stunted and non-stunted children in the work area of ​​Ganting Health Center, Gedangan District, Sidoarjo Regency. This study uses a quantitative approach with a 1:1 case control design paired by age and sex. The sample of this study was 60 children, consisting of 30 stunted children as the case group and 30 non-stunted children as the control group taken using a purposive sampling technique. Data collection on complementary feeding (MPASI) patterns was conducted using the Child Feeding Questionnaire (CFQ) and infectious disease history was obtained through interviews using a questionnaire. Data analysis used the McNemar test. The results of this study showed a significant difference in complementary feeding (MPASI) patterns (p = 0.035) and infectious disease history (p = 0.022) in stunted and non-stunted children in the working area of ​​the Ganting Health Center, Gedangan District, Sidoarjo Regency
Copyright (c) 2026 Nabila Aulia Rahmania, Amalia Ruhana https://creativecommons.org/licenses/by/4.0
BILATERAL PNEUMOTHORAX AS A COMPLICATION OF PULMONARY TUBERCULOSIS: A RARE AND LIFE-THREATENING CASE
Introduction: Bilateral spontaneous pneumothorax secondary to pulmonary tuberculosis is an uncommon but life-threatening complication characterized by the rupture of subpleural TB cavities with simultaneous air accumulation in both pleural spaces. It predominantly occurs in patients with advanced cavitary disease or immunocompromise and carries high morbidity and mortality without prompt recognition and management. Early imaging and combined emergency thoracic intervention with anti-tuberculosis therapy are essential to improving patient outcomes. Case Illustrations: A 46-year-old male presented with two months of progressive dyspnea, productive cough, weight loss, night sweats, and acute chest pain. Chest radiography confirmed bilateral pneumothoraces. Bilateral chest tubes were placed, and sputum GeneXpert detected rifampicin-sensitive Mycobacterium tuberculosis. Anti-tuberculosis therapy (Category I regimen) was initiated concurrently. By day 12, air leaks resolved, chest tubes were removed on day 13, and the patient was discharged in stable condition under outpatient TB follow-up. Discussion: Bilateral TB-related pneumothorax arises from cavitary rupture or bronchopleural fistula formation. Although unilateral pneumothorax is well described in TB, bilateral presentation remains rare. Management requires immediate needle decompression or chest tube insertion, high-flow oxygen, nutritional and analgesic support, and prompt initiation of rifampicin-based anti-tuberculosis therapy to address the underlying infection and facilitate cavity healing. Persistent air leaks may necessitate video-assisted thoracoscopic surgery with chemical or mechanical pleurodesis. Close radiological and microbiological monitoring during treatment minimizes recurrence risk. Conclusion: This case underscores the critical need for rapid diagnosis and integrated medical-surgical management of bilateral pneumothorax in pulmonary tuberculosis. Timely chest drainage combined with effective anti-tuberculosis therapy can lead to full lung re-expansion and favorable outcomes, even in resource-limited settings.
Copyright (c) 2026 Amiruddin, Muhammad Rizky Assilmy Lubis https://creativecommons.org/licenses/by/4.0
THE EFFECT OF FAMILY SUPPORT AND COMPLIANCE IN CONTROL OF LOW-PURINE DIET PATTERNS ON HYPERURICEMIA IN BOJONEGORO BASED ON LAWRENCE GREEN'S THEORY
Hyperuricemia is a condition characterized by elevated uric acid levels in the blood, which can cause joint pain and impaired activity in the elderly. Adherence to a low-purine diet and family support are important factors in preventing hyperuricemia. This study aimed to analyze the effect of family support and adherence to a low-purine diet on hyperuricemia based on Lawrence Green's theory. This study used a quantitative correlational design with a cross-sectional approach. The study sample consisted of 48 elderly people aged ≥ 60 years at the Elderly Posyandu in Tlatah Village, Purwosari District, Bojonegoro Regency, selected using a simple random sampling technique. The independent variables were family support and adherence to a low-purine diet, while the dependent variable was hyperuricemia. Data collection used questionnaires and uric acid examination observation sheets. Data analysis used a logistic regression test with a significance level of α <0.05. The results showed that the family support variable had a significant p value of 0.020 (<0.05), which means there is an effect of family support on hyperuricemia in the elderly. The Exp(B) value of 0.134 indicates that elderly people with good family support have a lower chance of experiencing hyperuricemia. The low-purine diet adherence variable showed a significant p value of 0.002 (<0.05), which means there is an effect of low-purine diet adherence on hyperuricemia in the elderly. The Exp (B) value of 0.061 indicates that elderly people who adhere to a low-purine diet have a lower risk of hyperuricemia. The conclusion of this study is that family support and adherence to a low-purine diet influence the incidence of hyperuricemia in elderly people. Good family support and adherence to a low-purine diet can help reduce the risk of hyperuricemia in elderly people
Copyright (c) 2026 Alfina Lutfiati, Evita Muslima Isnanda Putri, Sri Mulyani, Ahmad Mafthukin, Rahmawati https://creativecommons.org/licenses/by/4.0
THE RELATIONSHIP BETWEEN SELF-ESTEEM AND PUBLIC SPEAKING ANXIETY AMONG STUDENTS OF RAJEKWESI HEALTH COLLEGE, BOJONEGORO
Public speaking anxiety is a common psychological problem experienced by students and can be influenced by an individual's level of self-esteem. This study aims to analyze the relationship between self-esteem and public speaking anxiety among students at Rajekwesi Health College, Bojonegoro. The study used a quantitative approach with a correlational design and cross-sectional method. The study population was 461 students with a sample of 70 respondents selected using quota sampling techniques. The research instruments used were the Rosenberg Self-Esteem Scale (RSES) and the Hamilton Anxiety Rating Scale (HARS). Data analysis was performed using the Spearman Rho test with a significance level of 5%. The results showed that students with high self-esteem tended to have lower levels of public speaking anxiety. Statistical tests showed a significant relationship between self-esteem and public speaking anxiety in students. The conclusion of this study is that self-esteem plays an important role in influencing the level of public speaking anxiety, so that increasing self-esteem can help improve students' communication skills.
Copyright (c) 2026 M. Nashihul Hikam, Evita Muslima Isnanda Putri, Agus Ari Afandi, Rahmawati https://creativecommons.org/licenses/by/4.0
Maternal Nutrition Knowledge and Complementary Feeding Intake in Wasting and Non-Wasting Children Aged 6–24 Months in the Ganting Community Health Center Area, Gedangan, Sidoarjo
Wasting in children aged 6-24 months remains a nutritional problem that requires attention because it can hinder their growth and development. This study aims to analyze differences in maternal nutritional knowledge and complementary feeding intake in wasting and non-wasting children aged 6-24 months in the Ganting Community Health Center, Gedangan, Sidoarjo. The study used an observational analytical quantitative design with a matched case-control approach. The study population was children aged 6–24 months and their mothers. The sample consisted of 66 respondents, namely 33 wasting children and 33 non-wasting children, selected through purposive sampling and individual matching based on age and sex. Data were collected using a maternal nutritional knowledge questionnaire, a single 24-hour dietary recall, and anthropometric measurements. Data analysis was performed univariate analysis and bivariate analysis using the McNemar test and the Odds Ratio (OR) with a 95% confidence level. The results showed a significant difference in maternal nutritional knowledge (p=0.003; OR=5.66) and fulfillment of the Minimum Acceptable Diet (MAD) (p=0.019; OR=3.75) between the wasting and non-wasting groups. This study found, low maternal nutritional knowledge and failure to meet the Minimum Acceptable Diet (MAD) was associated with an increased risk of wasting among children aged 6-24 months
Copyright (c) 2026 Ahkamia Adila Putri, Amalia Ruhana https://creativecommons.org/licenses/by/4.0
ANALYSIS OF THE AVAILABILITY OF POSYANDU FACILITIES AND INFRASTRUCTURE AND ITS INFLUENCE ON PARTICIPATION OF HEALTH SERVICE TARGETS IN SUKADANA VILLAGE, TERARA DISTRICT, EAST LOMBOK REGENCY, WEST NUSA TENGGARA
Posyandu (Integrated Health Post) is a form of Community-Based Health Effort (UKBM) that plays a crucial role in improving public health. The success of Posyandu activities is greatly influenced by the availability of adequate facilities and infrastructure and the active participation of the community as the target of health services. This study aims to analyze the availability of Posyandu facilities and infrastructure and their influence on the participation of health service targets in Sukadana Village, Terara District, East Lombok Regency. This study used descriptive qualitative methods with data collection techniques through observation, interviews, and documentation. Informants consisted of Posyandu cadre leaders, cadres, and related parties who support the implementation of health services. The results showed that the main Posyandu facilities and infrastructure, such as baby scales, digital scales, and height measuring devices, were available and still suitable for use. However, there were still limitations in supporting facilities such as service tables and chairs. The availability of adequate facilities and infrastructure influenced the smooth running of health services and the level of community participation. The low participation of some targets was influenced by busy factors, health conditions, and limited time and mobility. Therefore, ongoing support from village governments and health workers is needed to improve the quality of facilities, the capacity of cadres, and community participation in integrated health post activities.
Copyright (c) 2026 Leni Lestari, Nurul Humairo, Nurul Humairo, Sherina Fazirawati, Lalu Zahrul Basim https://creativecommons.org/licenses/by/4.0
ANALYSIS OF PALLIATIVE NURSING CARE FOR POST-OP CRANIOTOMY A/I SPONTANEOUS INTRACEREBRAL HEMORRHAGE (ICH) PATIENTS WITH PAIN MANAGEMENT INTERVENTION IN THE ICU OF ROYAL PRIMA HOSPITAL MEDAN IN 2026
Intracerebral Hemorrhage (ICH) is a critical neurological condition with a high mortality rate that often requires craniotomy and intensive care in the ICU. Post-craniotomy patients generally experience acute pain that can worsen neurological conditions if not optimally managed. This study aims to analyze palliative nursing care in post-op craniotomy patients due to spontaneous intracerebral hemorrhage with pain management interventions in the ICU of Royal Prima Medan Hospital in 2026. The study used a case study method with a nursing process approach. The study population was post-op craniotomy patients with ICH in the ICU, with a sample of one 56-year-old female patient. Data collection was carried out through observation, physical examination, family interviews, and medical record documentation. The pain assessment instrument used the Critical Care Pain Observation Tool (CPOT), while data analysis was conducted descriptively. The results showed a decrease in CPOT pain scores from 7 to 5 after the administration of pharmacological and non-pharmacological pain management interventions. Patients also showed more stable hemodynamic conditions and a reduced response to the ventilator. The conclusion of the study shows that palliative nursing care with a focus on pain management is effective in helping to increase comfort and support the stability of the condition of post-craniotomy patients with ICH in the ICU.
Copyright (c) 2026 Cut Lianda Faradila, Idaman Kristiani Waruwu, Noniatri Ziliwu, Putri Nurul Izzah Andini, Seni Rofil Sandyani Mendrofa, Basri https://creativecommons.org/licenses/by/4.0
FORMULATION AND ACTIVITY TESTING OF AN ANTI-ACNE MICELLAR WATER FORMULATION CONTAINING BINAHONG LEAF EXTRACT (ANREDERA CORDIFOLIA TEN) AGAINST PROPIONIBACTERIUM ACNES
Acne (Acne vulgaris) is a chronic inflammation of the pilosebaceous glands caused by the bacteria Propionibacterium acnes and is a common skin problem, especially in adolescents with a prevalence of up to 85%. Binahong leaves (Anredera cordifolia) are known to contain secondary metabolites such as flavonoids, saponins, tannins, and alkaloids that have antibacterial potential. This study aims to formulate micellar water preparations from binahong leaf ethanol extract as an anti-acne facial cleanser and to evaluate its physical, chemical characteristics and antibacterial activity against Propionibacterium acnes bacteria. This study used a laboratory experimental method. Binahong leaf extract was obtained through a maceration method using 70% ethanol with a yield of 16.4%. Micellar water preparations were formulated in three variations of extract concentrations, namely 1%, 3% and 5%. Evaluation of the preparations included organoleptic tests, homogeneity, pH, viscosity, cleaning power, stability using the cycling test method and antibacterial activity testing using the disc diffusion method with clindamycin as a positive control. The results of the study showed that binahong leaf extract positively contained flavonoids, saponins, tannins, and alkaloids. All micellar water preparation formulas had good physical and chemical characteristics, were homogeneous, stable during testing, and had a pH that matched the physiological pH of facial skin. The results of the antibacterial activity test showed that preparations F1, F2 and F3 had antibacterial activity in the strong category with an average inhibition zone diameter of 11.35 ± 1.11 mm; 11.97 ± 2.40 mm; and 12.92 ± 0.56 mm. Based on the results of the study, the formula with a 5% extract concentration showed the best antibacterial activity against Propionibacterium acnes.
Copyright (c) 2026 Sintia Nurmala, Kartika Sari https://creativecommons.org/licenses/by/4.0
RELATIONSHIP BETWEEN EFFECTIVENESS AND VARIATIVENESS OF BRONCHIAL ASTHMA MEDICATION WITH CLINICAL IMPROVEMENT OF BRONCHIAL ASTHMA
Background: Bronchial asthma is a chronic inflammatory airway disease that is highly heterogeneous, both in terms of pathophysiology and response to therapy. The availability of various drug classes ranging from inhaled corticosteroids (ICS), bronchodilators, allergen immunotherapy (AIT), to various biologic agents does not necessarily guarantee uniform clinical improvement in every patient due to variability in endotypes, biomarkers, and treatment adherence. Objective: This review aims to analyze the relationship between the effectiveness and variability of various bronchial asthma drug classes with clinical improvement outcomes, including reduced exacerbations, improved lung function, and quality of life. Methods: A narrative literature review was compiled based on three main articles on allergen immunotherapy, targeted biologic therapy, and tezepelumab in severe asthma, supplemented by additional literature searches on therapy adherence and predictive biomarkers. Results and discussion: The effectiveness of conventional pharmacotherapy is strongly influenced by variability in patient adherence, with the average objective adherence to ICS ranging from 22 - 70% of the prescribed dose. Allergen immunotherapy has demonstrated consistent preventive and therapeutic effects in mild-moderate allergic asthma, but its benefits depend on dose, duration, and patient phenotype. Biologic therapy (anti-IgE, anti-IL-5/IL-5Rα, anti-IL-4Rα) significantly reduced exacerbations, particularly in the type 2-high phenotype with eosinophilia, while tezepelumab, a TSLP inhibitor, demonstrated efficacy across phenotypes, including type 2-low, with annual exacerbation reductions of up to 56–71%. This variability in response underscores the need for biomarker-guided approaches and combination therapies to optimize clinical improvement. Conclusion: The effectiveness of bronchial asthma medications is closely linked to the variability of disease endotypes, patient biomarkers, and therapy adherence; optimal clinical improvement is achieved through a personalized approach based on phenotypes and biomarkers, rather than a single, uniform treatment strategy.
Copyright (c) 2026 Natalia Kristina Br Sinaga https://creativecommons.org/licenses/by/4.0
Comparison of Lipstick Preparation Formulations of Red Dragon Fruit Extract (Hylocereus polyrhizus) and Aloe vera Extract (Aloe vera L.) as a Lip Colorant and Moisturizer with Lipstick Preparations Without Extracts
Lipstick is a type of cosmetic widely used to beautify the appearance of the lips. Excessive use of artificial colors can cause irritation, so safer natural ingredients are needed. Red dragon fruit peel (Hylocereus polyrhizus) contains natural dyes betacyanin which has the potential as a natural dye and antioxidant, while Aloe vera acts as a natural moisturizer. This study aims to explore the potential of red dragon fruit peel extract and Aloe vera in making lipstick and assess its physical quality and antioxidant activity. The research methodology includes dragon fruit peel extraction using maceration techniques and Aloe vera extraction using infundation methods, which are then formulated into lipstick with cera alba, carnauba wax, cetyl alcohol, and vaseline album as the base ingredients. Product evaluation includes organoleptic tests, pH, homogeneity, spreadability, hardness, irritation, melting point, weight uniformity, cyclic stability testing, and antioxidant activity using the DPPH method. The results showed that the lipstick formula using the extract produced a bright red color, a pH of 5, was stable at extreme temperatures, non-irritating, and had an antioxidant activity of 1.13 mgQE/g. It is hoped that this research can provide an alternative for the development of natural-based cosmetics that are safe, environmentally friendly, and provide antioxidant and moisturizing benefits to the lips.
Copyright (c) 2026 Athaya Wijdan Pascadiksa, Fitra Kamila Rahma, Elvina Widyasari Amarylis, Verna Wimala Salsabila, Dzikrina Adibah Salma https://creativecommons.org/licenses/by/4.0
ANTIBACTERIAL ACTIVITY OF BEET EXTRACT ( BETA VULGARIS L. ) AGAINST GRAM-POSITIVE BACTERIA: SYSTEMATIC LITERATURE REVIEW
Increasing antibiotic resistance in Gram-positive bacteria is driving the development of alternative antibacterial agents based on natural ingredients. Beetroot ( Beta vulgaris L. ) is known to contain betalain and phenol that have antibacterial potential. This study aims to analyze the antibacterial activity of Beet extract against Gram-positive bacteria and evaluate the effect of concentrations, solvents, and testing methods based on the literature during the period 2016–2026. Systematic Literature Review was conducted using the PRISMA protocol through literature searches on Publish or Perish, Google Scholar, ScienceDirect, and DOAJ databases. A total of 20 articles that met the inclusion criteria were analyzed based on the value of the inhibition zone diameter (ZI) and the Minimum Inhibitory Concentration (MIC). Beet extract showed antibacterial activity against various Gram-positive bacteria, one of which was Staphylococcus aureus with an inhibition zone range of <5–25 mm and a MIC of 0.012–32 mg/mL. Ethanol is the most widely used solvent, while the agar well diffusion method tends to produce a larger inhibition zone than disc diffusion. Beet tuber extract has the potential to be developed as a natural antibacterial source against various Gram-positive bacteria.
Copyright (c) 2026 Sagita Ananda, Reynatha Pangisibidang, Dita Wahyuningtias https://creativecommons.org/licenses/by/4.0
THE CORRELATION BETWEEN CRYSTALLOID FLUID PRELOADING AND BLOOD PRESSURE IN PATIENTS UNDERGOING CESAREAN SECTION WITH SPINAL ANESTHESIA AT THE CENTRAL SURGICAL INSTALLATION
Spinal anesthesia for cesarean section often causes maternal hypotension in 60-70% of cases, so an effective fluid management strategy is needed. This study aims to analyze the relationship between crystalloid fluid pre-loading and blood pressure changes in patients with spinal anesthesia for cesarean section. A quantitative, analytical, observational study with a cross-sectional design was conducted on 51 patients from a population of 58 at Dr. R. Goeteng Taroenadibrata Purbalingga Regional General Hospital (January-February 2026). Purposive sampling and the Slovin formula were selected. Data were collected through observation sheets and Drager NIBP monitors, and bivariate analysis was carried out using Fisher's Exact Test. The results showed that 76.5% received adequate pre-loading (10-20 ml/kgBW) with a hypotension incidence of 12.8% versus 66.7% in the inadequate group (p=0.001). The findings confirmed a significant relationship between adequate crystalloid pre-loading and blood pressure stability. Pre-loading of 10-20 ml/kgBW is recommended for elective cases to minimize the risk of hypotension.
Copyright (c) 2026 Aurelia Anaya Dwi Pradianita, Nurul Fatwati Fitriana, Marta Tania Gabriel Ching Cing, Tati Hardiyani https://creativecommons.org/licenses/by/4.0
FACTORS RELATED TO THE PRESENCE OF AEDES SP. MOSQUITO LARVAE IN THE IMPLEMENTATION OF MOSQUITO NEST ERADICATION IN THE WORKING AREA OF THE KENALI BESAR COMMUNITY HEALTH CENTER IN JAMBI CITY IN 2026
Dengue Hemorrhagic Fever remains a public health problem influenced by preventive behavior and home environmental conditions. This study aims to analyze factors related to the presence of Aedes sp. larvae in the implementation of PSN in the Kenali Besar Community Health Center, Jambi City, in 2026. This study is an observational analytic study with a cross-sectional design. The study population was all heads of families in the Kenali Besar Community Health Center, with a sample of 110 houses selected through simple random sampling. The research instruments were questionnaires, observation sheets, and hygrothermometers, while the data were analyzed using the chi-square test. The results showed a significant relationship between knowledge, attitudes, PSN actions, the role of health workers, and humidity with the presence of Aedes sp. larvae, while temperature was not significantly related. In conclusion, larva control is more related to behavioral factors and home microenvironment, so health education, strengthening jumantik cadres, and consistency of PSN need to be continuously strengthened
Copyright (c) 2026 Muthiah Fauziyyah Syadiq, Oka Lesmana, Andree Aulia Rahmat, Rd. Halim https://creativecommons.org/licenses/by/4.0
THE INFLUENCE OF FAMILY SUPPORTIVE ORGANIZATIONAL CULTURE ON WORK-FAMILY CONFLICT IN WORKING MOTHERS
The increasing participation of women in the workforce has expanded the role of mothers as individuals responsible not only for their families but also for the demands of their jobs. This condition increases the risk of work-family conflict (WFC), a conflict that arises from a misalignment between the demands of work and family life. This conflict has been identified as a critical issue in industrial and organizational psychology because it affects psychological well-being, job satisfaction, organizational commitment, productivity, and employee turnover intentions. One organizational factor believed to be able to reduce work-family conflict is family supportive organizational culture (FSOC), an organizational culture that supports a balance between work and family through policies, values, norms, and support from leaders and colleagues. This conceptual article aims to examine the relationship between family supportive organizational culture and work-family conflict in working mothers through a synthesis of theories and the results of recent empirical research. The study was conducted using a narrative literature review method by examining various scientific articles published in accredited national journals and reputable international journals in the fields of psychology, organizational behavior, and human resource management. The study results show that a family-friendly organizational culture acts as an organizational resource capable of reducing work-family conflict through work flexibility, supervisor support, coworker support, easy access to family-friendly policies, and reduced stigma against employees who carry out family responsibilities. Based on Conservation of Resources Theory , Role Theory , and Spillover Theory , FSOC contributes to creating a balance between work and family roles so as to improve the psychological well-being of working mothers. This article emphasizes that strengthening a family-friendly organizational culture is an important strategy in supporting work-family balance and sustainable organizational performance and serves as a foundation for future empirical research.
Copyright (c) 2026 Liandra Khairunnisa, Hafiz Nurdiansyah https://creativecommons.org/licenses/by/4.0
THE EFFECT OF MINDFULNESS THERAPY ON ENVIRONMENTAL ADAPTATION ANXIETY IN NEW FEMALE STUDENTS AT THE DARUL HIKMAH BALEN ISLAMIC BOARDING SCHOOL, BOJONEGORO BASED ON ROY'S ADAPTATION THEORY
New female students at Islamic boarding schools often experience environmental adaptation anxiety due to significant changes in their social environment and lifestyle. This condition can affect their emotional balance, learning process, and adjustment abilities. Mindfulness therapy is known as a non-pharmacological intervention that can improve emotional regulation and reduce anxiety. This study aims to analyze the effect of mindfulness therapy on environmental adaptation anxiety in new female students at Darul Hikmah Balen Islamic Boarding School in Bojonegoro based on Roy's Adaptation Theory. The study used a quantitative pre-experimental design with a one-group pretest-posttest approach. The study population consisted of 23 new female students, with a sample of 20 respondents selected using purposive sampling. Data collection used a mindfulness therapy module and the Hamilton Anxiety Rating Scale (HARS) questionnaire. Data analysis was performed univariately and bivariately using the Friedman test in SPSS 20.0. The results showed that before the intervention, 85% of respondents experienced severe anxiety. After four sessions of mindfulness therapy for two weeks, all respondents (100%) experienced mild anxiety. The statistical test results showed a p-value of 0.000 (<0.05), indicating a significant effect of mindfulness therapy on environmental adaptation anxiety. The conclusion of this study is that mindfulness therapy is effective in reducing environmental adaptation anxiety in new female students at Islamic boarding schools.
Copyright (c) 2026 Syani Laily Anggrina, Evita Muslima Isnanda Putri, Agus Ari Afandi, Sri Mulyani https://creativecommons.org/licenses/by/4.0
EFFECTIVENESS OF EDUCATION ON REPRODUCTIVE HEALTH IN IMPROVING KNOWLEDGE AND ATTITUDES TOWARD CHILD MARRIAGE PREVENTION AT THE ADOLESCENT POSYANDU IN TRUCUK
Family planning coverage at the Sadar Jaya Community Health Center in Siak Kecil Subdistrict, Bengkalis Regency, showed that out of 353 pregnant women, only 1 was an IUD user (IUD contraceptive use remained low compared to other non-MKJP contraceptives). This study aimed to examine the effect of counseling using leaflets on improving postpartum IUD family planning knowledge among third-trimester pregnant women. This was a pre-experimental study. The population comprised of all third-trimester pregnant women in May 2026, totaling 45 individuals; total sampling was used. Data analysis used the t-test. The results showed that prior to the education session, the majority (57.2%) of participants had adequate knowledge of postpartum IUD contraception. After the education session, the majority (66.7%) had good knowledge of postpartum IUD contraception. The effect of education using leaflets on the improvement of postpartum IUD knowledge among third-trimester pregnant women had a p-value of 0.000 < 0.05. The conclusion of this study is that health education using leaflets has an effect on increasing knowledge of postpartum IUD family planning among pregnant women in their third trimester. Therefore, improve their knowledge and understanding, particularly in providing services to pregnant women, regarding postpartum IUD family planning for pregnant women in their third trimester.
Copyright (c) 2026 Vera farida, Lisviarose, Dilgu Mery, Hirza Rahmita https://creativecommons.org/licenses/by/4.0
ANALYSIS OF THE EFFECTIVENESS OF THE SIBANGMAN WEBSITE AS AN INFORMATION MEDIA FOR REPORTING STUNTING INFORMATION AT THE BAPPEDA OF JAMBI CITY
This study was motivated by the importance of government websites as media for stunting information and reporting that support cross-sector coordination, data transparency, and the acceleration of stunting reduction programs. The study aimed to analyze the effectiveness of the SIBANGMAN Website as a stunting reporting information medium at the Regional Development Planning Agency of Jambi City based on the human, organization, technology, and fit aspects. This study employed a qualitative approach with a descriptive design. Informants were selected purposively and consisted of one key informant, three main informants, and six supporting informants from related regional agencies. Research instruments included interview guidelines, observation sheets, audio recorders, field notes, and documentation. Data were collected through in-depth interviews, observation, and documentation, while data analysis was conducted using data reduction, data display, and conclusion drawing supported by source triangulation. The findings showed that the SIBANGMAN Website was quite effective in supporting stunting reporting through an integrated system, good information quality, and strong organizational support, although challenges remained in digital literacy, automatic notification features, and system interface design. The study concludes that SIBANGMAN has fulfilled its informative and coordinating functions in stunting reporting, yet further technical development and user capacity strengthening are still required to optimize its sustainability and effectiveness.
Copyright (c) 2026 Rahma Dina Sari, Arnild Augina Mekarisce, Adila Solida, Rumita Ena Sari https://creativecommons.org/licenses/by/4.0
OVERVIEW OF BLOOD SUGAR LEVELS WHEN USING THE POINT OF CARE TESTING (POCT) METHOD
Blood glucose level is an important indicator used to assess the body’s metabolic condition and detect the risk of diabetes mellitus. University students are considered vulnerable to unhealthy lifestyle changes, including irregular eating patterns, lack of physical activity, academic stress, and insufficient sleep, which may affect blood glucose regulation. This study aimed to describe random blood glucose levels using the Point-Of-Care Testing (POCT) method among students of the Medical Laboratory Technology Study Program, Class of 2025, at Politeknik Cendrawasih Palu. This research employed a descriptive study with a cross-sectional approach. The sample consisted of 34 students who met the inclusion criteria. Blood glucose examination was performed using a POCT glucometer with capillary blood samples obtained from the fingertip. The results showed that all respondents had random blood glucose levels within the normal range, with values ranging from 89–161 mg/dL and an average level of 110.41 mg/dL. These findings indicate that the respondents generally had good glucose metabolism. The POCT method proved to be practical, rapid, and effective for early blood glucose screening and health monitoring among students.
Copyright (c) 2026 Dewi Herlyana Putri, Ni Komang Eva Dwi Yanti, Ni Luh Yesi Pratami, Wandy Christiawan Lampaga, Agung Surya Rahman, Moh Arif, Saskirana, Fitri Aramadani, Novita Fitri Fajriani, Mujizat https://creativecommons.org/licenses/by/4.0
Ethical Considerations and Informed Consent in Anesthesiology
In anesthesiology, ethical principles such as autonomy, beneficence, non-malfeasance, and justice are critical. This paper investigates these ethical considerations, emphasizing the process of obtaining informed consent. It addresses the unique challenges in anesthesiology, including the effects of anesthesia on patient cognition, the complexity of information, and the urgency often associated with anesthesia in emergency settings. The paper explores the implications of these challenges on obtaining valid consent and offers strategies to improve informed consent practices. These strategies include enhancing communication, providing pre-operative education, and ensuring thorough documentation. By adhering to these practices, anesthesiologists can better respect patient autonomy, mitigate risks, and uphold ethical standards in their practice. The goal is to ensure that patients are fully informed and able to participate meaningfully in decisions about their anesthesia care, even in complex and time-sensitive situations.
Copyright (c) 2026 Sofi Showkat Saleem, Dr.Qumail Hussain, Shuja Abass https://creativecommons.org/licenses/by/4.0
THE EFFECT OF BANANAS (MUSA PARADISIACA) ON REDUCING BLOOD PRESSURE IN PREGNANT WOMEN
Hypertension in pregnancy is one of the leading causes of maternal and fetal morbidity and mortality worldwide. This study aims to analyze the effect of banana (Musa paradisiaca) consumption on reducing blood pressure in pregnant women with hypertension. The research method used was a literature review of 20 research articles consisting of quasi-experimental, pre-experimental, and case study designs. The population in this study were pregnant women with hypertension, while the sample consisted of 20 research results that met the inclusion criteria. Instruments used in these studies included a sphygmomanometer and a blood pressure observation sheet. Data analysis was conducted using narrative synthesis of relevant research results. The results showed that most studies reported a significant decrease in systolic and diastolic blood pressure after consuming bananas at a dose of 100–200 grams per day for 5–14 days, with a p value <0.05. Ambon bananas are the most frequently used type and have shown consistent effectiveness as a complementary therapy. The conclusion of this study is that banana consumption has an effect on lowering blood pressure in pregnant women with hypertension and can be used as a complementary non-pharmacological therapy, although there are still limitations in sample size and research design.
Copyright (c) 2026 Lisna Nurfitriana, Siti Mardhatillah Musa https://creativecommons.org/licenses/by/4.0
Child marriage remains a significant issue in Indonesia, including in Trucuk District, Bojonegoro Regency. One preventive effort that can be carried out is through reproductive health education at the Adolescent Posyandu. Health education aims to increase knowledge and shape better attitudes in preventing child marriage among adolescents. This study aims to analyze the effectiveness of reproductive health education in increasing knowledge and attitudes toward child marriage prevention at the Adolescent Posyandu in Trucuk. This study uses a quantitative method with a pre-experimental one-group pretest-posttest design. The research sample consists of adolescents actively participating in the Adolescent Posyandu in Trucuk, selected using purposive sampling techniques. Data were collected through questionnaires before and after the reproductive health education intervention. Data analysis was performed using a Wilcoxon Rank to assess changes before and after the education. The study results indicate a significant increase in adolescent knowledge and attitudes after receiving reproductive health education (p-value = 0.000 a <0.05). adolescents who previously had limited understanding of reproductive health and the risk of child marriage showed increased awareness and more positive attitudes after receiving the education. Reproductive health education has proven effective in enhancing knowledge and shaping better attitudes in preventing child marriage at the Adolescent Posyandu in Trucuk. This education program can serve as a recommended strategy for broader implementation to reduce child marriage rates in Indonesia.
Copyright (c) 2026 Alfa Khamdia, Sri Mulyani, Siti Patonah https://creativecommons.org/licenses/by/4.0
MATERNAL KNOWLEDGE OF COMPLEMENTARY FEEDING, COMPLEMENTARY FEEDING INTAKE, AND HISTORY OF EARLY COMPLEMENTARY FEEDING INTAKE AMONG STUNTED AND NON-STUNTED CHILDREN AGED 12–24 MONTHS IN THE GANTING COMMUNITY HEALTH CENTER AREA, GEDANGAN DISTRICT, SIDOARJO
Stunting remains a major nutritional problem in children under two years old (toddlers), and one factor suspected to play a role is the practice of providing complementary feeding intake to breast milk (MPASI). This study aims to analyze differences in maternal knowledge regarding MPASI, MPASI intake, and history of early MPASI provision in stunted and non-stunted children aged 12–23 months in the Ganting Community Health Center Working Area, Gedangan District, Sidoarjo Regency. The study used an observational analytical design with a matched case-control approach. The study population was toddlers aged 12–23 months and their mothers. The sample consisted of 60 mother-child pairs selected by purposive sampling: 30 stunted children as the case group and 30 non-stunted children as the control group, matched by age and gender. Data were collected using a MPASI knowledge questionnaire, interviews regarding the history of early MPASI provision, the 24-hour dietary recall method, and anthropometric measurements. Data analysis was performed using the McNemar test and Odds Ratio (OR) calculation. The results showed a significant difference in maternal knowledge regarding complementary feeding (p<0.001) and history of early complementary feeding (p=0.022), while complementary feeding intake based on the Minimum Acceptable Diet indicator did not show a significant difference (p=0.332). It was concluded that low maternal knowledge and a history of early complementary feeding were factors that differentiated the stunted and non-stunted groups, while complementary feeding intake did not show a significant difference
Copyright (c) 2026 Zaqia Saila Safani, Amalia Ruhana https://creativecommons.org/licenses/by/4.0
IN SILICO STUDY OF PHYSALIS ANGULATA COMPOUNDS AS POTENTIAL THERAPEUTICS FOR ECZEMATIC SKIN DISEASES
Eczema, a broad term encompassing a number of chronic inflammatory skin disorders, is typically characterized by symptoms such as redness (erythema), itching (pruritus), dryness, thickening of the skin due to repeated scratching (lichenification), and the possible appearance of fluid (exudation) or small blisters (vesicles). IL-4 and IL-13 activate the JAK-STAT pathway through the IL-4Rα and IL-13Rα1 receptors, which promotes STAT6 activation and the inflammatory response in atopic dermatitis, thus providing the basis for the use of upadacitinib as a selective JAK1 inhibitor that is effective in alleviating the symptoms of the disease. The aim of this study was to explore potential therapeutic pathways, with particular attention to compounds present in Physalis angulata , including the withanolide group such as withangulain B, physagulin C, and withanolide, which is one of 41 groups of compounds that have been identified in Physalis angulata . In addition, this study also evaluated the control drug upadacitinib, which is designed to target the IL-4Rα and IL-13Rα1 receptors, which play a key role in the type 2 (Th2) immune response. The study utilized several computational techniques, including data mining, biological activity analysis, ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling, molecular mapping, and in silico studies. The results showed that the binding energies of the ligands (Physagulin C and Withangulatin B) with the IL-4Rα receptor were -12.6 kcal/mol and -12.7 kcal/mol, respectively. Similarly, Withanolide and Withagulatin B were identified as the top candidate compounds for the IL-13Rα1 receptor, with binding energies of -11.5 and -11.5 kcal/mol, respectively. The interactions above are the most beneficial for the development of eczematic disease therapy. The overall results of this study demonstrate great potential, indicating that the withanolide compounds, physagulin c, and withangulatin B derived from Physalis angulata offer an alternative pathway in targeting immune cells (Th2) through JAK-STAT activation and STAT6 translocation to the nucleus. Therefore, this study opens up opportunities for the development of innovative therapies in the treatment of eczematic diseases.
Copyright (c) 2026 Yan Martin Witantra https://creativecommons.org/licenses/by/4.0
ANTIOXIDANT CREAM FORMULATION OF PORANG TUBER ETHANOL EXTRACT AS AN ANTI-AGING AGENT
Irreversible skin aging begins in early adulthood due to intrinsic factors such as genetics and cellular metabolism and extrinsic factors such as ultraviolet exposure, smoking, pollution, and lifestyle, which trigger reactive oxygen species (ROS) and collagen damage, leading to wrinkles and reduced skin elasticity. This study aimed to formulate an optimal anti-aging cream from ethanol extract of porang tubers (Amorphophallus muelleri Blume) using variations in the HLB value of Span 60-Tween 80 emulsifiers. This quantitative experimental study used three cream formulas (F1: HLB 4.95; F2: HLB 5.7; F3: HLB 6.8) prepared from 3 kg of porang tubers obtained from Sirapit, Langkat. Evaluations included organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesiveness, cycling-test stability, irritation, preference, and antioxidant activity using the DPPH method. The results showed that F2 was the optimal formula, with medium viscosity, spreadability of 6.2 cm², pH 5.8, stability for six cycles, and an IC₅₀ value of approximately 114 μg/mL, indicating moderate antioxidant activity. Formula F2 therefore has potential as a topical antioxidant preparation for preventing premature skin aging based on locally sourced tropical material.
Copyright (c) 2026 Ain Naia, Roy Indrianto Bangar, Hariyadi Dharmawan Syahputra https://creativecommons.org/licenses/by/4.0
EFFICACY OF CONSUMING DATES (PHOENIX DACTYLIFERA) IN OVERCOMING GESTATIONAL FATIGUE AND ANEMIA IN SECOND TRIMESTER PREGNANT WOMEN: LITERATURE REVIEW
Pregnancy fatigue and anemia are common conditions in pregnant women in the second trimester and can increase the risk of maternal and fetal complications. Dates (Phoenix dactylifera) contain iron, folic acid, vitamin B complex, and natural sugars that have the potential to increase hemoglobin levels and energy metabolism. This study aims to analyze the efficacy of date consumption in overcoming gestational fatigue and anemia in pregnant women in the second trimester. The study used a literature review method by examining scientific articles from 2020–2025 obtained from the PubMed and Google Scholar databases. The study population consisted of articles related to date consumption, gestational fatigue, anemia, and pregnant women, with a sample of 12 articles consisting of 6 national journals and 6 international journals. The research instrument used a literature review sheet and data analysis was carried out descriptively through synthesis of research results. The results showed that consuming 6–7 dates (70–100 grams) per day for at least 14 days can increase hemoglobin levels by 0.965–2.3 g/dL and improve labor parameters related to reduced fatigue. The combination of dates and iron supplements has been shown to be more effective than iron supplements alone. In conclusion, dates are an effective and safe non-pharmacological intervention to help treat anemia and fatigue in pregnant women.
Copyright (c) 2026 Muliatul Jannah, Rifana Azizatul Khairani https://creativecommons.org/licenses/by/4.0
The Relationship Between Socio-Economical and Pregnancy Spacing with the Incidence of Chronic Energy Deficiency (CED) in Pregnant Women at the Balen Community Health Center
Chronic Energy Deficiency (CED) remains a serious nutritional problem among pregnant women in Indonesia, particularly in the Balen Community Health Center (Puskesmas) area of ​​Bojonegoro Regency. Socioeconomic status and pregnancy spacing are suspected to contribute to the incidence of CED. The purpose of this study was to determine the relationship between socioeconomic status and pregnancy spacing and the incidence of CED in pregnant women. This study used a cross-sectional design with a sample size of 44 pregnant women drawn using simple random sampling. The independent variables were socioeconomic status and pregnancy spacing, while the dependent variable was the incidence of CED as measured by mid-upper arm circumference (MUAC). Data analysis used the Spearman's Rho test with a significance level of <0.05. The study showed that less than half of the pregnant women had low socioeconomic status (19 women (43.2%), and most of the pregnant women had a safe/ideal pregnancy spacing (37 women (84.1%). The results of the analysis using sperm rank showed a significant association between economic status and the incidence of CED (p = 0.000). women, while pregnancy spacing did not show a significant association. Nutrition education interventions and ideal pregnancy planning are needed to prevent CED.
Copyright (c) 2026 Yuli Anggraeni, Siti Patonah, Wiwik Utami, Fidrotin Azizah https://creativecommons.org/licenses/by/4.0
ANALYSIS OF FACTORS INFLUENCING THE ACCURRENCE OF DRUG STAGNANT AND STOCKOUTS AT THE MAUK COMMUNITY HEALTH CENTER, TANGERANG REGENCY
Drug logistics is a process intended to achieve a specific goal that is carried out effectively and efficiently in the management of drugs to achieve predetermined objectives. The purpose of this study was to analyze drug management at the Mauk Community Health Center based on the guidelines of Ministry of Health Regulation No. 74 of 2016 and to analyze the factors that influence drug stagnation and stockouts at the Mauk Community Health Center. This study was a non-experimental, descriptive study using a cross-sectional observational method. The results of this study show that drug management at the Mauk Community Health Center UPTD is in accordance with the requirements of the 2016 Minister of Health Regulation No. 74 concerning pharmaceutical service standards at community health centers. However, there are still several obstacles in its implementation. One of the main obstacles is the length of time required for the procurement of drugs and disposable medical supplies. The conclusion of this study shows that stagnation and stockouts at the Mauk Community Health Center UPTD are caused by poor implementation of drug requests, as evidenced by only 22% of drug requests matching drug receipts and 78% of drug receipts not matching drug requests, as well as drug shortages or limitations from the Health Office, resulting in a mismatch between drug requests and drug receipts.
Copyright (c) 2026 Jaka Supriyanta, Endang Sunariyanti, Lukman Hadi Permana https://creativecommons.org/licenses/by/4.0
Potential of Phytochemical Compounds from Natural Products as Anticancer Agents: A Systematic Literature Review
Cancer is one of the leading causes of death worldwide, necessitating the development of more effective and safe anticancer therapies. Phytochemical compounds from natural sources hold great potential due to their diverse biological activities. This study aims to assess the potential of phytochemical compounds as anticancer agents through a systematic literature review of fifteen scientific articles selected based on specific inclusion criteria and analyzed qualitatively. The results indicate that compounds such as flavonoids including quercetin, polyphenols, alkaloids, and terpenoids have anticancer activity through inhibition of cell proliferation, induction of apoptosis, and inhibition of angiogenesis and metastasis, mediated by molecular pathways such as p53, nuclear factor kappa B, and caspases. In addition, approaches such as nanoformulation and combination therapy can improve the efficacy and bioavailability of the compounds. These findings indicate that phytochemical compounds have the potential to be safer and more effective anticancer agents, and require further research for clinical development
Copyright (c) 2026 Saeful Amin, Azka Najhan, Aldy Arifin Ilham, Annisa Septiani https://creativecommons.org/licenses/by/4.0
PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF ETHANOLIC EXTRACT OF Chromolaena odorata LEAVES
Chromolaena odorata leaves are empirically known to act as anti-inflammatory and other pharmacological effects. In this study, ethanol extracts from Chromolaena odorata leaves were analyzed using phytochemical screening and gas chromatography-mass spectrometry (GC-MS) to identify phytochemical constituents. Phytochemical tests showed the presence of flavonoids, alkaloids, tannins, saponins, and phenolics. GC-MS analysis of ethanol extracts from Chromolaena odorata leaves detected the presence of seven phytochemical compounds, namely Ethyl (E)-4-(2-phenylethylamino)but-2-enoate; 2h-pyran 2-(7-heptadecynyloxy) tetrahydro; 3,7,11-Trimethyldodeca-2,6,10-trienyl acetate; Bicyclo(3.1.1)heptane, 2,6,6-trimethyl-,(1alpha,2beta,5alpha)-11,13-Dimethyl-12-tetradecen-1-yl acetate; (2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-ol, and 9,12,15-Octadecatrienoic acid. This study identified several constituents that are biologically active compounds through GC-MS. These phytocompounds have potential as herbal medicines due to pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, antibacterial, and anticancer.
Copyright (c) 2026 Aditya Candra, Tahara Dilla Santi, Ika Waraztuty, Syarifah Nora Andrianty, Andri, Said Aandy Saida https://creativecommons.org/licenses/by/4.0
IMPLEMENTATION OF HOT BATH HYDROTHERAPY AND MOIST WOUND HEALING INNOVATIONS IN NURSING CARE FOR SKIN INTEGRITY DISORDERS IN TYPE 2 DM PATIENTS IN THE ORCHID ROOM OF SUNGAILIAT REGIONAL GENERAL HOSPITAL IN 2026
Background: Type 2 Diabetes Mellitus often causes diabetic ulcers that cause impaired skin integrity and increase the risk of infection, amputation, and decreased quality of life. The combination of Hot Bath Hydrotherapy and Moist Wound Healing is a nursing innovation that has the potential to support wound healing. Objective: To describe the application of Hot Bath Hydrotherapy and Moist Wound Healing innovations in nursing care for type 2 Diabetes Mellitus patients with impaired skin integrity in the Anggrek Ward, Bakti Timah Hospital, Sungailiat in 2026. Method: The study used a descriptive design with a descriptive case study approach. The study subjects were 10 type 2 Diabetes Mellitus patients with diabetic ulcers who met the inclusion criteria. Data were collected using a nursing assessment format, wound development observation sheet, Bates-Jensen Wound Assessment Tool or Pressure Ulcer Scale for Healing, documentation, interviews, observations, and physical examinations. Data analysis was carried out descriptively by comparing the patient's condition before and after the intervention. Results: All patients showed improvement in wound condition in the form of reduced exudate and necrotic tissue, increased granulation tissue, decreased pain, reduced signs of infection, and increased mobility after 3 x 24 hours of intervention. Conclusion: The combination of Hot Bath Hydrotherapy and Moist Wound Healing has the potential to be an evidence-based nursing intervention that supports the healing of diabetic ulcers and improves the quality of nursing care.
Copyright (c) 2026 Mega Artika, Shindi Hapsari https://creativecommons.org/licenses/by/4.0
THE EFFECT OF MUROTTAL AL-QUR'AN THERAPY ON PAIN IN POST-SECTION CAESAREAN PATIENTS WITH SPINAL ANESTHESIA
Pain in post-caesarean section patients with spinal anesthesia remains a major problem that can hinder maternal recovery, early mobilization, and breastfeeding. This study aims to determine the effect of Quranic recitation therapy on pain in post-caesarean section patients with spinal anesthesia at Banjarnegara Islamic Hospital. This study used a quantitative method with a pre-experimental one-group pretest-posttest design. The study population consisted of all post-caesarean section patients at Banjarnegara Islamic Hospital, with a sample of 40 respondents selected using purposive sampling. The research instruments included a Numerical Rating Scale and a respondent characteristics sheet. Data analysis was performed using a paired sample t-test. The results showed that the average pain level before the intervention was in the moderate pain category, while after the intervention it decreased to the mild pain category. There was a significant effect of Quranic recitation therapy on reducing pain in post-caesarean section patients with spinal anesthesia. In conclusion, Quranic recitation therapy is effective as a non-pharmacological intervention for reducing postoperative pain.
Copyright (c) 2026 Umi Sakdiyah, Wilis Sukmaningtyas, Dwi Novitasari, Daryanto, Awal Tunis Yantoro https://creativecommons.org/licenses/by/4.0
NON-COMMUNICABLE DISEASES (NCDs) CHOLESTEROL THROUGH POINT OF CARE TESTING (POCT) IN LABUAN BAJO VILLAGE, BANAWA DISTRICT, DONGGALA REGENCY
Hypercholesterolemia is a pathological condition characterized by excessive accumulation of cholesterol in the blood that can trigger serious cardiovascular complications, including coronary heart disease and stroke. This study aims to describe the distribution of total cholesterol levels and the level of community knowledge regarding non-communicable diseases (NCDs) in Labuan Bajo Village through the Point of Care Testing (POCT) method. A descriptive survey method with a qualitative approach was employed, involving 17 respondents from RT 01 and RT 02, Labuan Bajo Village, Banawa District, Donggala Regency, on January 15, 2026. Capillary blood samples were examined using the NESCO Multicheck N-01 device. Results revealed that 41.2% of respondents had high cholesterol levels (≥240 mg/dL), 23.5% were at borderline high (200-239 mg/dL), and 35.3% had normal levels (<200 mg/dL). Furthermore, 82.3% of respondents demonstrated low to very low knowledge about hypercholesterolemia. Key contributing factors include advanced age, high-fat dietary habits of coastal communities, and limited access to health information. POCT proved effective and efficient as a community-based early detection instrument for non-communicable diseases.
Copyright (c) 2026 Tiara Agustina, Siti Nurhaliza Hinelo, Vadyan Raehandy Thufeil, Nursabita Chaerani, Yescika Tricia Torae, Yuyun Dinda Sauru, Zahwa Radilva, Nurfadila, Shinta Nugraini, Kholid Mu'tasim, Revalina Febriani A. Hasan, Salsabila https://creativecommons.org/licenses/by/4.0
ANALYSIS OF OXYTOCIN MASSAGE AND BREAST CARE ON SMOOTH BREAST MILK PRODUCTION IN POSTPARTUM MOTHERS
Breast milk is the most comprehensive biological nutrition for infants, yet the coverage of exclusive breastfeeding in postpartum mothers has not yet reached global targets. Delays in breast milk production, maternal stress, and lack of lactation support are factors that influence breastfeeding success. This study aims to analyze the effectiveness of oxytocin massage and breast care on smooth breast milk production in postpartum mothers. The study used a qualitative research method with a systematic literature review approach. The study population was scientific articles discussing oxytocin massage, breast care, and breast milk production in postpartum mothers in 2020–2025. The study sample consisted of 20 articles selected purposively based on inclusion and exclusion criteria. The research instruments included an article search sheet, inclusion and exclusion criteria, and a data extraction matrix. Data analysis was conducted using content analysis and narrative synthesis. The results showed that oxytocin massage and breast care significantly increased breast milk production, facilitated milk letdown, reduced maternal stress, and improved breastfeeding comfort. The combination of the two interventions provided more optimal results than either intervention alone. The conclusion of this study is that oxytocin massage and breast care are non-pharmacological interventions that are effective, safe, and easy to implement to support the success of exclusive breastfeeding in postpartum mothers
Copyright (c) 2026 Nadia Fitri, Siti Mardhatillah Musa, Atnesia Ajeng https://creativecommons.org/licenses/by/4.0
DESCRIPTION OF THE LEVEL OF KNOWLEDGE AND BEHAVIOR OF DIABETES MELLITUS PREVENTION IN STUDENTS OF THE D-IV MEDICAL LABORATORY TECHNOLOGY STUDY PROGRAM, CLASS OF 2025.
Diabetes Mellitus is a chronic metabolic disease characterized by elevated blood glucose levels due to impaired insulin production or function. This study aimed to describe the level of knowledge about Diabetes Mellitus among students of the D-IV Medical Laboratory Technology Study Program, class of 2025. This descriptive study used a cross-sectional approach involving 34 respondents through questionnaire distribution. The results showed that 52.9% of respondents had good knowledge, 35.3% had sufficient knowledge, and 11.8% had poor knowledge. Students still showed limited understanding regarding diabetes complications and normal blood glucose levels. Overall, students demonstrated a fairly good level of knowledge about Diabetes Mellitus.
RELATIONSHIP BETWEEN WIDAL TITER WITH C-REACTIVE PROTEIN (CRP) LEVELS AND SEGMENTED NEUTROPHIL PERCENTAGE IN CHILDREN WITH TYPHOID FEVER AT GRAHA MEDIKA MARTAPURA CLINIC, BANJAR DISTRICT
Typhoid fever is an infectious disease that remains a public health problem in Indonesia, particularly among children. Infection with Salmonella typhi can trigger an inflammatory response characterized by elevated C-reactive protein (CRP) levels and changes in the percentage of segmented neutrophils. The Widal test is still widely used to aid in the diagnosis of typhoid fever because it is simple, rapid, and cost-effective. This study aimed to determine the relationship between Widal titers and CRP levels and the percentage of segmented neutrophils in pediatric typhoid fever patients at the Graha Medika Martapura Clinic, Banjar Regency. This study employed an observational analytical method with a cross-sectional design. The data used were secondary data from the medical records of pediatric typhoid fever patients from January 2025 to March 2026. The study sample consisted of 206 patients selected using total sampling. Data analysis was performed using the Spearman rank correlation test. The results showed that the majority of patients had a Widal titer of 1/640 (65.5%), elevated CRP levels (59.7%), and a normal percentage of segmented neutrophils (84.5%). The correlation test results showed no significant association between the Widal titer and CRP levels (r=0.073; p=0.296) or the percentage of segmented neutrophils (r=0.064; p=0.361). It was concluded that the Widal titer is not associated with CRP levels or the percentage of segmented neutrophils in pediatric patients with typhoid fever.
Copyright (c) 2026 Eka Wahyuni, Puspawati, Muhammad Arsyad, Syihab Fayumi https://creativecommons.org/licenses/by/4.0