ANTIOXIDANT CREAM FORMULATION OF PORANG TUBER ETHANOL EXTRACT AS AN ANTI-AGING AGENT

Ain Naia; Roy Indrianto Bangar; Hariyadi Dharmawan Syahputra

doi:10.59733/medalion.v7i2.292

Authors

Ain Naia Universitas Prima Indonesia
Roy Indrianto Bangar Universitas Prima Indonesia
Hariyadi Dharmawan Syahputra Universitas Prima Indonesia

DOI:

https://doi.org/10.59733/medalion.v7i2.292

Keywords:

Anti-Aging, Antioxidant, DPPH, HLB, Porang

Abstract

Irreversible skin aging begins in early adulthood due to intrinsic factors such as genetics and cellular metabolism and extrinsic factors such as ultraviolet exposure, smoking, pollution, and lifestyle, which trigger reactive oxygen species (ROS) and collagen damage, leading to wrinkles and reduced skin elasticity. This study aimed to formulate an optimal anti-aging cream from ethanol extract of porang tubers (Amorphophallus muelleri Blume) using variations in the HLB value of Span 60-Tween 80 emulsifiers. This quantitative experimental study used three cream formulas (F1: HLB 4.95; F2: HLB 5.7; F3: HLB 6.8) prepared from 3 kg of porang tubers obtained from Sirapit, Langkat. Evaluations included organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesiveness, cycling-test stability, irritation, preference, and antioxidant activity using the DPPH method. The results showed that F2 was the optimal formula, with medium viscosity, spreadability of 6.2 cm², pH 5.8, stability for six cycles, and an IC₅₀ value of approximately 114 μg/mL, indicating moderate antioxidant activity. Formula F2 therefore has potential as a topical antioxidant preparation for preventing premature skin aging based on locally sourced tropical material.

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References

Anindhita, M., & Arsanto, C. (2020). Formulasi krim ekstrak daun kersen (Muntingia calabura L.) dengan variasi kombinasi Span 60 dan Tween 80 sebagai emulgator. Jurnal Ilmiah Farmasi, 9(2), 50-60. https://doi.org/10.30591/pjif.v9i2.2034

Bangar, R. I., Ningsih, K. N., Kartasasmita, R. E., & Insanu, M. (2024). Isolation of α-glucosidase enzyme inhibitor from titanus (LeeaaequataL.).

Cahyani, A. S., & Erwiyani, A. R. (2022). Formulasi dan uji sun protection factor (SPF) sediaan krim ekstrak etanol 70% daging buah labu kuning (Cucurbita maxima Duch) secara in vitro. Journal of Pharmacy, 2(1), 1-11. https://doi.org/10.37013/jf.v2i1.149

Creswell, J. W., & Creswell, J. D. (2022). Research design: Qualitative, quantitative, and mixed methods approaches (6th ed.). SAGE Publications.

Depkes RI. (1978). Farmakope Indonesia (Edisi II). Departemen Kesehatan Republik Indonesia.

Erwati. (2021). Penuaan kulit dan faktor penyebabnya. Jurnal Kesehatan Indonesia, 12(3), 45-52.

Hidayati, R., Sari, D. E. M., & Noor, N. (2023). Formulasi sediaan krim ekstrak wortel (Daucus carota L.) dan uji aktivitasnya sebagai tabir surya secara in vitro. Jurnal Farmasi Sains dan Terapan, 10(1), 25-31. https://doi.org/10.33508/jfst.v10i1.4467

Istiqomah, N. F., & Muhtadi, M. (2021). Penetapan kadar glukomanan dan asam oksalat dalam ekstrak etanol umbi porang (Amorphophallus muelleri Blume) beserta uji aktivitas antioksidan dan antibakterinya. Proceeding of The URECOL, 582-592.

Marbun, J., Sihombing, R., & Simanjuntak, P. (2023). Aktivitas antioksidan ekstrak etanol umbi porang (Amorphophallus muelleri Blume) dengan metode DPPH. Media Nusa Pharmaceutical Journal, 2(1), 25-30. https://doi.org/10.55589/mnpj.v2i1.52

Masaki, H. (2010). Role of antioxidants in the skin: Anti-aging effects. Journal of Dermatological Science, 58(2), 85-90. https://doi.org/10.1016/j.jdermsci.2010.03.003

Mukkun, L., Songgor, K., Lalel, H. L., Rubak, Y. T., Roefaida, E., Tae, A. S. A., & Nalle, R. P. (2022). Karakteristik fisik, kadar air, dan kandungan glukomanan tepung porang (Amorphophallus muelleri Blume) melalui beberapa teknik perendaman. Jurnal Agrisa, 11(2), 122-130.

Pratasik, M. C. M., Yamlean, P. V. Y., & Wiyono, W. I. (2019). Formulasi dan uji stabilitas fisik sediaan krim ekstrak etanol daun sesewanua (Clerodendron squamatum Vahl). Pharmacon, 8(2), 261-270. https://doi.org/10.35799/pha.8.2019.29289

Shin, J. W., Kwon, S. H., Choi, J. Y., Na, J. I., Huh, C. H., Choi, H. R., & Park, K. C. (2023). Molecular mechanisms of dermal aging and antiaging approaches. International Journal of Molecular Sciences, 24(21), 15733. https://doi.org/10.3390/ijms242115733

Silva, S., Ferreira, M., Oliveira, A. S., & Reis, R. L. (2024). Antiaging effects of a skin care formulation containing nanoencapsulated antioxidants: A clinical, in vitro, and ex vivo study. Journal of Cosmetic Dermatology, 23(3), 789-798. https://doi.org/10.1111/jocd.15976

Siregar, N., Bangar, R. I., Kaban, V. E., & Simanjuntak, N. J. P. (2025). Antioxidant Activity Test of The Aqueous Fraction of Tetanus Leaves (Leea aequata L.) Using The DPPH Method. 03(01).

Sugiyono. (2021). Metode penelitian kuantitatif, kualitatif, dan R&D. Alfabeta.

Voigt, R. (1994). Pharmazeutische Technologie (8th ed.). Deutscher Apotheker Verlag.

Wang, Y., Zhang, X., & Liu, Y. (2023). Skin aging from mechanisms to interventions: Focusing on dermal extracellular matrix integrity. Frontiers in Physiology, 14, 1128059. https://doi.org/10.3389/fphys.2023.1128059

Widjaja, S., Santoso, B., & Nugroho, A. (2021). Formulasi dan uji stabilitas fisik sediaan krim ekstrak etanol daun sirih hijau. Jurnal Media Ummat Farmasi, 3(2), 78-85.

Winarsi, H. (2007). Antioksidan alami makanan, minuman, dan jamu. Nuha Medika.