Potential of Phytochemical Compounds from Natural Products as Anticancer Agents: A Systematic Literature Review

Saeful Amin; Azka Najhan; Aldy Arifin Ilham; Annisa Septiani

doi:10.59733/medalion.v7i2.285

Authors

Saeful Amin Bakti Tunas Husada University
Azka Najhan Bakti Tunas Husada University
Aldy Arifin Ilham Bakti Tunas Husada University
Annisa Septiani Bakti Tunas Husada University

DOI:

https://doi.org/10.59733/medalion.v7i2.285

Keywords:

Phytochemistry; Anticancer; Natural products; Molecular mechanisms; Systematic review

Abstract

Cancer is one of the leading causes of death worldwide, necessitating the development of more effective and safe anticancer therapies. Phytochemical compounds from natural sources hold great potential due to their diverse biological activities. This study aims to assess the potential of phytochemical compounds as anticancer agents through a systematic literature review of fifteen scientific articles selected based on specific inclusion criteria and analyzed qualitatively. The results indicate that compounds such as flavonoids including quercetin, polyphenols, alkaloids, and terpenoids have anticancer activity through inhibition of cell proliferation, induction of apoptosis, and inhibition of angiogenesis and metastasis, mediated by molecular pathways such as p53, nuclear factor kappa B, and caspases. In addition, approaches such as nanoformulation and combination therapy can improve the efficacy and bioavailability of the compounds. These findings indicate that phytochemical compounds have the potential to be safer and more effective anticancer agents, and require further research for clinical development

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References

Amin, S., Amelia, NP, Ramadhan, TO, & Putri, SD (2025). Medicinal Chemistry Approach in Optimizing Bioactive Compounds from Natural Ingredients as Anticancer Drug Candidates.

Amin, S., Amelia, NP, Ramadhan, TO, & Putri, SD (2025). Medicinal Chemistry Approach in Optimizing Bioactive Compounds from Natural Materials as Anticancer Drug Candidates Bakti Tunas Husada University, Indonesia design, development, and synthesis of drugs. In recent years, approach. (April).

Amin, S., Fariidah, FN, & Kalimatillah, AR (2025). The Role of Computational Medicinal Chemistry in Identification of Anti-Cancer Agents through Molecular Docking of Natural Compounds.

Amin, S., Fariidah, FN, & Kalimatillah, AR (2025). The Role of Computational Medicinal Chemistry in Identifying Anti-Cancer Agents through Molecular Docking of Natural Compounds. 8(11), 6767–6776. https://doi.org/10.56338/jks.v8i11.8888

Amin, S., Rusiyana, NP, Pujiyani, D., & Azzahara, SM (2024a). Evaluation of the Anticancer Potential of Moringa Leaf Compounds through Medicinal Chemistry.

Amin, S., Rusiyana, NP, Pujiyani, D., & Azzahara, SM (2024b). Evaluation of Anticancer Potential of Moringa Leaf Compounds through Medicinal Chemistry. 4(1), 75–82.

Amin, S., Wihdatunnisa, I., Aisyah, R., & Kurniawan, YS (2024). Potential of Quercetin Compound as an Anti-Breast Cancer Agent through Molecular Docking Approach.

Amin, S., Wihdatunnisa, I., Aisyah, R., & Kurniawan, YS (2024). Potential of Quercetin Compound as Breast Anticancer through Molecular Docking Approach. 4(1), 41–51.

Bioactive, S., & Cancer, PT (2025). P. 183. 2(2), 183–190.

Bioactive, S., & Cancer, PT (2025). Bioactive Compound Approach to Cancer Therapy.

Bozzuto, G., & Calcabrini, A. (2024). Phytocompounds and nanoformulations for anticancer therapy: A review.

Budiarto, R., Sholikin, MM, & Adli, DN (2025). Antioxidant and anticancer properties of citrus-mediated nanoformulations.

Budiarto, R., Sholikin, MM, & Adli, DN (2025). Antioxidant and anticancer properties of citrus-mediated nanoformulations revealed by. 1–22.

Diphenhydramine Hydrochloride Drug Monograph. (2020). US Food and Drug Administration.

Elrayess, R. A., & El-hak, H. N. G. (2025). A Review of Natural Anticancer Products.

Fakudze, N., & Sarbadhikary, P. (2026). Enhanced anticancer potential of Punica granatum fruit extract in combination with photodynamic therapy.

Fakudze, N., Sarbadhikary, P., Abrahamse, H., & George, B. P. (2026). Enhanced anticancer potential of Punica granatum fruit extract in combination with Pheophorbide-a mediated photodynamic therapy on MCF-7 breast cancer cells. 143–161.

Farmasi, F., Bakti, U., & Husada, T. (2023). In Silico Study of Mangosteen Peel Compounds as Breast Anticancer.

Farmasi, F., Bakti, U., Husada, T., & No, JC (2023). In Silico Study of Compounds Contained in Mangosteen Peel (Garcinia mangostana L.) as Anti-Breast Cancer Proceedings of the National Seminar on Research Dissemination Volume 3 of the Pharmacy Undergraduate Study Program 2023, Bakti Tunas Husada University. 3(September), 276–286.

Hançer, A. (2026a). Antioxidant and Anticancer Potentials of Apple Peel and Fruit Extracts.

Hançer, A. (2026b). Antioxidant and Anticancer Potentials of Apple Peel and Fruit Extracts : A Combined Docking and Chemical Composition Study. 1–30.

Naeem, A., Hu, P., & Yang, M. (2022). Natural Products as Anticancer Agents: Current Status and Future Perspectives.

Naeem, A., Hu, P., Yang, M., Zhang, J., Liu, Y., Zhu, W., & Zheng, Q. (2022). Natural Products as Anticancer Agents : Current Status and Future Perspectives.

Nisa, AL, & Amin, S. (2025). Exploration of the Potential of Natural Compounds as Lung Anticancer Candidates.

Nisa, AL, Amin, S., Bakti, U., & Husada, T. (2025). EXPLORATION OF THE POTENTIAL OF NATURAL COMPOUNDS AS LUNG ANTICANCER CANDIDATES THROUGH MOLECULAR DOCKING APPROACH: 2(3), 432–439.

Nur, S., Mohamad, A., & Shameli, K. (2023). Enhanced antibacterial and anticancer activities of plant extract mediated green synthesized zinc oxide-silver nanoparticles.

Nur, S., Mohamad, A., Shameli, K., Teow, S., Chew, J., Ooi, L., Soon, ML, Ismail, NA, & Moeini, H. (2023). Enhanced antibacterial and anticancer activities of plant extract mediated green synthesized zinc oxide-silver nanoparticles. (July), 1–14. https://doi.org/10.3389/fmicb.2023.1194292

Ramdhiani, ND, & Amin, S. (2025). Flavonoids as Anticancer Agents.

Ramdhiani, ND, Amin, S., Farmasi, PS, Farmasi, F., Bakti, U., & Husada, T. (2025). DOI: https://doi.org/10.59841/an-najat.v3i4.3411. 3, 12–22.

Reports, S. (2026a). Green synthesis, characterization, evaluation of anticancer and antioxidant potentials of gold and copper oxide nanoparticles using jujube fruit extract.

Reports, S. (2026b). Scientific Reports Article in Press Green synthesis , characterization , evaluation of anticancer and antioxidant potentials of gold and copper oxide nanoparticles using jujube fruit extract IN AR IN.

Situmorang, PC, & Ilyas, S. (2024). Prospects of compounds of herbal plants as anticancer agents.

Wang, Q., & Li, D. (2024). Dietary isothiocyanates and anticancer agents.

Zhou, X. (2024). Recent advances of tryptanthrin and its derivatives as potential anticancer agents.

Zhou, Z., & Nan, Y. (2024). Hawthorn with homology of medicine and food: A review of anticancer effects and mechanisms.